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Tobacco Stories: Diabetes Drug May Help Prevent Lung Cancer : Metformin linked to tumor reduction in mouse study
New research in mice suggests that metformin, a drug widely used to treat type 2 diabetes, may guard against lung cancer.The drugs prospects are not yet confirmed because researchers still need to test it in people. But, in mice, "this well-tolerated, FDA-approved diabetes drug was able to prevent tobacco carcinogen-induced lung tumors," Dr. Phillip A. Denn ...
Tobacco Stories: The cancer blame game
The blame that society puts on lung cancer patients could seriously impede attention and research funding on the disease, a local expert says."It gets 3 per cent of the total research funding for all cancers, and yet it is the No. 1 killer," says Dr. James Gowing, a Flamborough doctor and cochair of the Cancer Advocacy Coalition of Canada (CACC).A 16-country ...
Tobacco Stories: EDITORIAL: Cancer on the run: Indoor smoking bans and high taxes have helped discourage tobacco use, saving lives
The American Cancer Society recently reported some good news: Cancer is still on the run.Although men and women continue to get the disease in large numbers, the big change is found in cancer deaths. For men, death rates from cancer fell 21 percent between 1990 and 2006. Death rates for women fell 12.3 percent in that time. In all, some 767,000 deaths from c ...
Tobacco Stories: BROWN: Alex Hurricane Higgins, John Daly and the link between high-level sport and addiction
Alex "Hurricane" Higgins, who has died after more than 10 years battling with throat cancer, was one of those naturally talented sportsmen for whom success appears to come without effort. This inborn talent can present a problem. What to do to fill your time when yourenot playing? George Best was another of these inspired, natural players.The bottom line, o ...
Tobacco Stories: Yale Establishes Research Program on Addictive Behaviors in Women
Addictive behaviors in women involving tobacco, alcohol, illicit drugs and overeating will be the focus of a new five-year, $2.5 million faculty training grant awarded to Yale University researchers in the Department of Psychiatry.The grant, funded by the National Institute on Drug Abuse and the National Institutes of Health Office of Research on Womens Hea ...
Tobacco Stories: American Cancer Society Action Network: To reflect on successes and challenges in battle against cancer, Sen. Harkin is speci..
The American Cancer Society Cancer Action Network will celebrate its successes and embrace the challenges that lie ahead in the ongoing battle against cancer during a reception Saturday night in Iowa City. Senator Tom Harkin (D-IA), Chairman of the Senate Health, Education, Labor and Pensions Committee and the Appropriations Panel that funds health initiativ ...
Tobacco Stories: Study ties abnormal cells in blood to lung cancer
A novel approach detects genetically abnormal cells in the blood of non-small cell lung cancer patients that match abnormalities found in tumor cells and increase in number with the severity of the disease, a research team led by scientists at The University of Texas MD Anderson Cancer Center report in the journal Clinical Cancer Research.Lung cancer patient ...
Tobacco Stories: History of Smoking is Associated with Younger Age at Diagnosis of Breast Cancer: The Breast Journal Volume 16 Issue 4, Pages..
Smoking tobacco has been associated with incidence, response and outcomes after treatment of some cancers. We hypothesized that tobacco use could result in an observable effect on breast cancer stage and characteristics at diagnosis. There were 6,000 patients with Tis-4, N0-3 breast cancers who presented to a comprehensive cancer center at initial diagnosis ...
Tobacco Stories: Smoking history linked to younger breast cancer diagnoses: Breast J 2010; 16: 344349
A history of smoking is associated with a younger age at breast cancer diagnosis in White, but not Black women, US research shows."The mechanisms of possible relationships between smoking and breast cancer are not well understood," write Gary Freedman (Fox Chase Cancer Center, Philadelphia, Pennsylvania) and colleagues.Freedman and team hypothesized that if ...
Tobacco Stories: What happens to your genes when you smoke a cigarette?
The effects of smoking cigarettes on gene activity have been investigated in the largest study of its kind. Researchers writing in the open access journal BMC Medical Genomics studied white blood cells taken from 1,240 people to identify 323 unique genes whose expression levels were significantly correlated with smoking behavior.Jac Charlesworth led a team o ...
EDITORIAL: Cigarette Smoking and Breast Cancer Risk: Limited Evidence of Genotypic and Exogenous Carcinogenic Factors and The..
A new approach to the diagnosis of tobacco addiction. ($$): Addiction Volume 105 Issue 3, Pages 381 - 382 Published Online..
Commentary on Sims et al. (2010): The decline in passive smoking. ($$): Volume 105 Issue 3, Pages 554 - 555 Published Online:..
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·BROWN: Alex Hurricane Higgins, John Daly and the link between high-level sport and addiction
Alex "Hurricane" Higgins, who has died after more than 10 years battling with throat cancer, was one of those naturally talented sportsmen for whom success appears to come without effort. This inborn talent can present a problem. What to do to fill your time when yourenot playing? George Best was another of these inspired, natural players.The bottom line, of course, is that theyre addicts - thats why they drink so ...
·Behavioral economic analysis of cue-elicited craving for alcohol
Conclusions These findings support the potential utility of a behavioral economic approach to understanding the role of environmental stimuli in alcohol-related decision making. Specifically, they suggest that the behavioral economic indices of demand may provide complementary motivational information that is related to though not entirely redundant with measures of subjective craving.
·New analysis may help clarify the role of craving in addiction
Just-published research led by a psychologist at the University of Georgia shows that behavioral economic analysis may lead to an improved understanding of craving for alcohol and other drugs.This method of studying how craving alters the way a person values a drug is fairly new, but according to the study, it may well help assess cravings more accurately and contribute to identifying more effective ways to defeat ad ...
·New analysis may help clarify the role of craving in addiction
Just-published research led by a psychologist at the University of Georgia shows that behavioral economic analysis may lead to an improved understanding of craving for alcohol and other drugs.This method of studying how craving alters the way a person values a drug is fairly new, but according to the study, it may well help assess cravings more accurately and contribute to identifying more effective ways to defeat ad ...
·Smoking: Were wacky about our fix of the baccy
I WAS standing by my fathers hospital bed, while he told me that they were probably going to amputate his leg.I dragged out a pack of Carrolls with shaking hands, and lit up.A young doctor spoke from behind me. "Ive never seen a non-smoker in this ward," he said. I took another deep, calming drag."That woman over there is getting her arm amputated," he said softly. . . .If scientists came out with research that sa ...
·Genotype Score and Nicotine Dependence Guide Smoking Abstinence Strategy
A new study on smoking cessation focused on a personalized approach to smoking cessation, with attention to individuals genotypes and the dose-response effectiveness of nicotine replacement therapy (NRT), as related to smokers nicotine dependence. Higher-dose NRT was found to increase successful abstinence in more dependent smokers with low "quit-success" scores.The report notes that less than 1 person in 20 succes ...
·Smoking triggers more stress: Survey
Canadians hoping to blow off economic anxiety with cigarettes could get burned, according to new research linking smoking with significantly higher-than-normal stress levels.Drawing on data from 2,250 adults, Pew Research a non-partisan American think-tank found half (50 per cent) of all smokers claim to experience frequent stress in their lives, compared with just 35 per cent of ex-smokers and 31 per cent of non ...
·Habit, not nicotine, prompts cigarette cravings
Are smokers hooked on nicotine, or on the habit of smoking itself? Thats the question posed by an ingenious study on smokers who worked as flight attendants, which found cravings for the next cigarette were just as strong on short-haul as long-haul flights. The study authors say this suggests nicotine replacement therapy may not be the most effective way to help someone quit smoking. . . .Where does the study come f ...
·Smoking and Cloningers Temperament and Character Inventory
Cloningers neuropsychopharmacological theory identifies four temperament traits and three character traits that are largely heritable and are associated with addictions.Methods: We tested whether these personality traits were associated with smoking behavior and predicted smoking cessation and tobacco withdrawal symptoms. We conducted an Internet cohort study in 20052009. The Temperament and Character Inventory (TC ...
·Yale Establishes Research Program on Addictive Behaviors in Women
Addictive behaviors in women involving tobacco, alcohol, illicit drugs and overeating will be the focus of a new five-year, $2.5 million faculty training grant awarded to Yale University researchers in the Department of Psychiatry.The grant, funded by the National Institute on Drug Abuse and the National Institutes of Health Office of Research on Womens Health, will be used to train scholars to conduct interdiscipli ...
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·EDITORIAL: Cancer on the run: Indoor smoking bans and high taxes have helped discourage tobacco use, saving lives
The American Cancer Society recently reported some good news: Cancer is still on the run.Although men and women continue to get the disease in large numbers, the big change is found in cancer deaths. For men, death rates from cancer fell 21 percent between 1990 and 2006. Death rates for women fell 12.3 percent in that time. In all, some 767,000 deaths from cancer were avoided.Now the sobering news: an estimated 569,4 ...
·American Cancer Society Action Network: To reflect on successes and challenges in battle against cancer, Sen. Harkin is speci...
The American Cancer Society Cancer Action Network will celebrate its successes and embrace the challenges that lie ahead in the ongoing battle against cancer during a reception Saturday night in Iowa City. Senator Tom Harkin (D-IA), Chairman of the Senate Health, Education, Labor and Pensions Committee and the Appropriations Panel that funds health initiatives is ACS CANs special guest."We have made tremendous progr ...
·Painters Have a Brush With Bladder Cancer Risk
Painters and others exposed to paint on the job are at significantly greater risk of developing bladder cancer than other workers, even when potential confounders, such as smoking and other occupational exposures, are taken into account, say authors of a meta-analysis of 41 studies.Neela Guha, PhD, MPH, and colleagues from the International Agency for Research on Cancer in Lyon, France, report their findings in the A ...
·What happens to your genes when you smoke a cigarette?
The effects of smoking cigarettes on gene activity have been investigated in the largest study of its kind. Researchers writing in the open access journal BMC Medical Genomics studied white blood cells taken from 1,240 people to identify 323 unique genes whose expression levels were significantly correlated with smoking behavior.Jac Charlesworth led a team of researchers from the Southwest Foundation for Biomedical R ...
·Painters at significantly increased risk of bladder cancer: Bladder cancer risk in painters: a meta-analysis
Painters are at significantly increased risk of developing bladder cancer, concludes a comprehensive analysis of published evidence in Occupational and Environmental Medicine. . . .The authors base their findings on almost 3000 cases of bladder cancer arising in professional painters, reported in 41 separate studies.A key risk factor for the disease is smoking, but higher numbers than expected of bladder cancer have ...
·Smoking influences gene function, scientists say: Negative influence found on the immune system, strong involvement in proce...
In the largest study of its kind, researchers at the Southwest Foundation for Biomedical Research (SFBR) have found that exposure to cigarette smoke can alter gene expression -- the process by which a genes information is converted into the structures and functions of a cell. These alterations in response to smoking appear to have a wide-ranging negative influence on the immune system, and a strong involvement in pr ...
·Not Starting Means Never Having to Quit
My husbands fate was sealed at age 11, when he smoked his first cigarette. As he put it, "I got hooked that very day." Although he tried repeatedly to quit, he rarely abstained from nicotine longer than a tortured week or two.Finally, with the help of a hypnotist and nicotine gum, at age 61 he quit for good. But 50 years of smoking took its toll. Emphysema limited his stamina for a decade, and lung cancer killed him ...
·MEMO TO THE MEDIA: Smoking-related Colorectal Cancer in Older Women Is Associated with Molecularly Defined Changes in DNA
Smoking, an established risk factor for colon cancer, may induce specific epigenetic changes and gene mutations that may be involved in the development of colon cancer, according to an online study published June 29 in the Journal of the National Cancer Institute.Cigarette smoking is a risk factor for colorectal cancer, with a recent meta-analysis estimating that people who currently smoke or smoked in the past are 1 ...
·EDITORIAL: Clearing the Air on Smoking and Colorectal Cancer
There has been long-standing interest in the relationship between cigarette smoking and colorectal cancer. Epidemiological studies that were conducted 40 years ago failed to detect any association with smoking, and essentially, all causative factors were assumed to be found in the diet, which fit the wide range of incidence in gastrointestinal cancers found worldwide (1). Even the most current epidemiological meta-an ...
·Cigarette Smoking and Colorectal Cancer Risk by Molecularly Defined Subtypes
Conclusions: In this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related colorectal carcinogenesis.
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·EDITORIAL: Cigarette Smoking and Breast Cancer Risk: Limited Evidence of Genotypic and Exogenous Carcinogenic Factors and The...
No Abstract
·History of Smoking is Associated with Younger Age at Diagnosis of Breast Cancer: The Breast Journal Volume 16 Issue 4, Pages...
Smoking tobacco has been associated with incidence, response and outcomes after treatment of some cancers. We hypothesized that tobacco use could result in an observable effect on breast cancer stage and characteristics at diagnosis. There were 6,000 patients with Tis-4, N0-3 breast cancers who presented to a comprehensive cancer center at initial diagnosis between 1970 and 2006. Patients were included who had a know ...
·Smoking history linked to younger breast cancer diagnoses: Breast J 2010; 16: 344349
A history of smoking is associated with a younger age at breast cancer diagnosis in White, but not Black women, US research shows."The mechanisms of possible relationships between smoking and breast cancer are not well understood," write Gary Freedman (Fox Chase Cancer Center, Philadelphia, Pennsylvania) and colleagues.Freedman and team hypothesized that if tumors of smokers and nonsmokershave different etiology, the ...
·Second-hand smoke increases risk of breast cancer in young women
Studies on the possible relationship between cigarette smoke and breast cancer have been inconsistent, with some showing an increase in risk and others not.But after reviewing all available evidence more than 100 studies the panel concluded that all women who smoke, particularly young women, are at increased risk of breast cancer, and that even young women who dont smoke are at increased risk if theyre exposed ...
·* Medical News from ASCO: American Society of Clinical Oncology Meeting: Chicago, IL • June 4 - 8, 2010
ASCO: Age No Barrier to NSCLC Chemo ASCO: Selenium Fails to Prevent New Cancers ASCO: Antibody Improves Head and Neck Cancer ResultsASCO: Chemotherapy Plus Docetaxel Handled by Older Cancer Patients ASCO: New NSCLC Drug Creates StirASCO: Mouth Cancer Patients Do Better if Tumor is HPV-PositiveASCO: Non-Platinum Regimen Works in Head, Neck Cancer
·Smoking Ups Risk of Second Breast Cancer : 15 years after treatment, smokers more likely to have a new tumor, study finds
Breast cancer survivors who smoke are at increased risk for a second cancer, a new study shows.Researchers followed women who were diagnosed with early-stage breast cancer and underwent breast-conserving therapy, which consists of a lumpectomy followed by radiation therapy.Fifteen years after treatment, the overall risk of developing a new, second cancer was 25 percent in the 796 smokers and 19 percent in nonsmokers. ...
·Breast Cancer Survivors May Face Second Cancers if they Smoke
Women who survive early-stage breast cancer and smoke have an increased chance of developing a new second cancer in their other breast or elsewhere. Investigators from The Cancer Institute of New Jersey (CINJ) are releasing these findings at an oral presentation during the 92nd AnnualMeeting of the American Radium Society taking place this week in Cancun, Mexico. CINJ is a Center of Excellence of UMDNJ-Robert Wood Jo ...
·Nearly any lifetime smoking ups breast cancer risk: SOURCE: The Breast Journal, September/October 2009
Women taking the next puff of a cigarette might consider this: smoking 100 or more cigarettes may substantially increase their odds of developing breast cancer, researchers report.Previous studies linked regular exercise, limiting alcohol intake, and avoiding postmenopausal obesity as lifestyle changes that can reduce womens odds of developing breast cancer, notes Dr. Ivana T. Croghan and colleagues in The Breast Jo ...
·Scientists crack entire genetic code of cancer
Scientists have unlocked the entire genetic code of two of the most common cancers - skin and lung - a move they say could revolutionise cancer care.Not only will the cancer maps pave the way for blood tests to spot tumours far earlier, they will also yield new drug targets, says the Wellcome Trust team.Scientists around the globe are now working to catalogue all the genes that go wrong in many types of human cancer.
·Studies Quantify Cancer Risks From CT Scans : An estimated 29,000 future cancers could be linked to scans performed in 2007
Commonly performed CT scans are exposing patients to far more radiation than previously thought and in doses that could cause tens of thousands of cancers a year, two new studies claim.Based on the findings, reported in the Dec. 14/28 issue of the Archives of Internal Medicine, the study authors, joined by Archives editor Dr. Rita F. Redberg, are calling on clinicians to limit radiation exposure to patients."CT has b ...
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·EDITORIAL: Cancer on the run: Indoor smoking bans and high taxes have helped discourage tobacco use, saving lives
The American Cancer Society recently reported some good news: Cancer is still on the run.Although men and women continue to get the disease in large numbers, the big change is found in cancer deaths. For men, death rates from cancer fell 21 percent between 1990 and 2006. Death rates for women fell 12.3 percent in that time. In all, some 767,000 deaths from cancer were avoided.Now the sobering news: an estimated 569,4 ...
·Study ties abnormal cells in blood to lung cancer
A novel approach detects genetically abnormal cells in the blood of non-small cell lung cancer patients that match abnormalities found in tumor cells and increase in number with the severity of the disease, a research team led by scientists at The University of Texas MD Anderson Cancer Center report in the journal Clinical Cancer Research.Lung cancer patients in the study also had many times the number of these circu ...
·Easing the Pain of Lung Cancer
Several readers had questions for the Consults blog about the complications of lung cancer. Dr. Derek Raghavan of the Cleveland Clinic responds.When Lung Cancer Spreads to the BonesQ.After surgical removal of three lobes for primary adenocarcinoma tumors since 2000, I recently underwent radiation therapy for metastasis of lung cancer to the spine . . .When Lung Cancer Causes Bleeding in the ChestQ.What causes lung c ...
·Stereotactic Body Radiation Therapy for Lung Cancer a Key Topic for Elekta Presenters at Annual ASTRO Conference: Leading c...
The American Society for Radiation Oncology (ASTRO) has accepted four abstracts from users of Elekta Stereotactic Body Radiation Therapy (SBRT) technology on the use of SBRT to treat non-small cell lung cancer (NSCLC). The clinicians will present their findings during presentations atASTROs 52nd Annual Meeting (October 31 - November 4) at the San Diego Convention Center.NSCLC, the most common form of lung cancer, ar ...
·Not Starting Means Never Having to Quit
My husbands fate was sealed at age 11, when he smoked his first cigarette. As he put it, "I got hooked that very day." Although he tried repeatedly to quit, he rarely abstained from nicotine longer than a tortured week or two.Finally, with the help of a hypnotist and nicotine gum, at age 61 he quit for good. But 50 years of smoking took its toll. Emphysema limited his stamina for a decade, and lung cancer killed him ...
·Expert sees end to lung cancer epidemic
An award-winning public health advocate says lung cancer will most likely become an uncommon disease in Australia by 2050.Professor Simon Chapman says a ban on advertising, indoor smoking and health warnings on cigarette packets have contributed to a decline in the disease. . . .Professor Chapman says we could be seeing the beginning of the end of the lung cancer epidemic, thanks to government policy. . . .He says al ...
·Annual Review of Advances in Lung Cancer Clinical Research: A Report for the Year 2009
The use of positron emission tomography compared with conventional staging increases the detection of extrathoracic metastases and reduces the number futile thoracotomies in patients being evaluated for surgical resection. Long-term follow-up of one of the two adjuvant chemotherapy trials revealeda continued overall survival (OS) benefit to adjuvant chemotherapy. In locally advanced non-small cell lung cancer, a phas ...
·New method of tissue banking makes gene analysis more practical for lung cancer
Analyzing the genes expressed by cancer cells allows for a better understanding of that patients specific disease and in turn, a more personalized approach to treatment. But obtaining the RNA from a tumor in the lungs in order to conduct the genetic analysis is a challenging prospect. Currently, lung cancer researchers are limited to using RNA extracted from early-stage tumors removed during surgery. The small quant ...
·Many Lung Cancer Patients Stopped Smoking Years Before Diagnosis: Medscape Medical News from the: * 11th Interna...
Much of what people think they know about smoking and lung cancer might be wrong, according to findings presented here at the 11th International Lung Cancer Conference.For example, many if not most patients with a history of smoking quit decades before. In a retrospective study of 626 people with lung cancer treated at a tertiary-care facility in Southern California, 482 (77%) had a history of smoking. Of those, only ...
·The cancer blame game
The blame that society puts on lung cancer patients could seriously impede attention and research funding on the disease, a local expert says."It gets 3 per cent of the total research funding for all cancers, and yet it is the No. 1 killer," says Dr. James Gowing, a Flamborough doctor and cochair of the Cancer Advocacy Coalition of Canada (CACC).A 16-country survey released last week by the Global Lung Cancer Coaliti ...
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·Media Release - No better time to quit than now: World No Tobacco Day 2010: Canadian Diabetes Association urges Canadians li...
Smoking while having diabetes is a deadly combination - in recognition of the World Health Organizations (WHO) World No Tobacco Day taking place on May 31, 2010, the Canadian Diabetes Association is urging Canadians living with diabetes who smoke to take charge of their health by knowing their risks and to take action to quit smoking.Each year, an estimated 45,000 Canadians die of smoking-related illnesses.(1) Canad ...
·Tobacco use exacerbates diabetes
For years, Guam residents, and Pacific Islanders in general, have been told their genetic predispositions and heavy diets make them prime candidates for developing Type II, or adult-onset, diabetes.Through exercise and eating healthy, diabetes can be kept at bay.Wellness Works will get to diet in the coming weeks, but on your part, doctors, researchers and health educators say theres one thing you can do immediately ...
·FDA-approved metformin can prevent tobacco-carcinogen induced lung tumors: Study
Metformin, a mainstay of treatment for patients with type 2 diabetes, may soon play a role in lung cancer prevention if early laboratory research presented here at the AACR 101st Annual Meeting 2010 is confirmed in clinical trials.Metformin decreases levels of insulin-like growth factor-1 (IGF-1) and circulating insulin, which is important in patients with type 2 diabetes. However, emerging research suggests metformi ...
·Diabetes Drug May Help Prevent Lung Cancer : Metformin linked to tumor reduction in mouse study
New research in mice suggests that metformin, a drug widely used to treat type 2 diabetes, may guard against lung cancer.The drugs prospects are not yet confirmed because researchers still need to test it in people. But, in mice, "this well-tolerated, FDA-approved diabetes drug was able to prevent tobacco carcinogen-induced lung tumors," Dr. Phillip A. Dennis, senior investigator in the medical oncology branch of th ...
·Quitters at Risk of Developing Diabetes
Giving up cigarettes may increase a patients risk of type 2 diabetes, researchers say.In a longitudinal study, quitters had a 73% greater risk of the disease than never-smokers, Hsin-Chieh Yeh, PhD, of Johns Hopkins University, and colleagues reported online in the Annals of Internal Medicine.Yeh and her colleagues wrote that quitters "experienced relatively more adverse changes in their metabolic profile and an inc ...
·Smoking Cessation Linked To Diabetes, Quitters Should Watch Weight
New research suggests that quitting smoking may raise the risk of developing type 2 diabetes in the short term, and as ex-smokers log more years without touching cigarettes, that risk gradually comes down to that of a never-smoker; the researchers suspect weight gain is the main reason and warn quitters to watch their weight.These are the findings of a study by researchers from the Johns Hopkins University School of ...
·VIDEO: Study: Quitting smoking raises diabetes risk
STORY HIGHLIGHTS* People who quit smoking are at high risk of developing diabetes because of weight gain* Health benefits of quitting smoking far outweigh the risk of diabetes, doctors say* People in the study who quit smoking gained an average of 8.4 pounds
·Even quitting smoking can trigger illness
Cigarette smoking is so powerful that even the act of quitting may cause changes in body chemistry that impact ones health. In a study of more than 10,000 middle-aged people, researchers from Johns Hopkins University found both current smokers and recent quitters had a greater risk for type 2 diabetes.
·Smoking, Quitting Smoking, and the Risk for Type 2 Diabetes: Summaries for Patients
What are the implications of the study?When smokers quit, they should get advice about how to prevent weight gain and be monitored for diabetes in the years soon after quitting. Quitting smoking provides many health and other benefits. Persons should not continue to smoke to reduce diabetes risk. The best way to reduce the risk for smoking-related diabetes is not to start smoking.
·Smoking, Smoking Cessation, and Risk for Type 2 Diabetes Mellitus: A Cohort Study: January 5, 2010; 152 (1)
Conclusion: Cigarette smoking predicts incident type 2 diabetes, but smoking cessation leads to higher short-term risk. For smokers at risk for diabetes, smoking cessation should be coupled with strategies for diabetes prevention and early detection.
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